AIM: To explore the meaning of the level of D-dimer(D-D), fibrinogen(Fib)and fibrin degradation products(FDP)in serum for eye malignant tumor diagnosis and evaluation.

METHODS: Sixty-seven patients with eye malignant tumor(malignant tumor group)in our hospital were selected,among which, 44 as malignant tumor without metastasis group, 23 as malignant tumor with metastasis group; 46 patients were selected with eye benign tumor(benign tumor group)during the same time period; 30 healthy people visited our hospital for regular physical examination was elected simultaneously as the healthy control group. The level of D-D, Fib and FDP were detected in serum.

RESULTS: The D-D, Fib and FDP level in eye malignant tumor group was significantly higher than those in either the eye benign tumor group or the healthy control group(P<0.01), malignant tumor with metastasis group had the significant higher level of D-D, Fib and FDP than those of malignant tumor without metastasis group(P<0.05). There was no significant difference statistically between the eye benign tumor group and healthy control group of the serum level of D-D, Fib and FDP(P>0.05). There was significant difference of D-D level distribution among each group(P<0.05).

CONCLUSION: To detect the level of D-D, Fib and FDP in serum can help with differentiation the tumor from benign to malignancy, analysis the progression of tumor and prognosis.