AIM: To investigate the outcome of wavefront-guided laser in situ keratomileusis(LASIK)with femtosecond laser for correcting high myopia

METHODS: Thirty-two patients(58 eyes)with high myopia(myopia degree: -6.0～-10.0DS, astigmia degree ≤ -2.0DC)underwent wavefront-guided LASIK using femtosecond laser in Chongqing Aire Eye Hospital from October to December in 2012 were collected as wavefront group, and 28 patients(56 eyes)with high myopia(myopia degree: -6.0～-10.0DS, astigmia degree ≤ -2.0DC)receiving LASIK with femtosecond laser were chosen as control group. These patients were followed up for 6 months. Uncorrected visual acuity(UCVA), refraction, total high order aberrations(HOA), spherical values and coma values between two groups were compared.

RESULTS: Six months after the operation, UCVA of all eyes were higher than 0.8. UCVA achieved 1.0 or better, which account for 91.4% of eyes in wavefront group and 87.5% in control group, the difference was not statistically significant(P=0.360). UCVA achieved 1.2 or better in 60.3% of eyes in wavefront group and 57.1% in control group, the difference was not statistically significant(P=0.729). UCVA achieved 1.5 or better in 17.2% of eyes in wavefront group and 12.5% in control group, the difference was not statistically significant(P=0.477). The coma values were lower in wavefront group than that in control group, the difference was statistically significant(P=0.021). There was no statistically significant difference in postoperative UCVA, refractions, total HOA and spherical values between two groups(P>0.05).

CONCLUSION: Compared with conventional LASIK with femtosecond laser, although wavefront-guided LASIK with femtosecond laser canreduce the coma values of patients with high myopia, wavefront-guided LASIK with femtosecond laser has no adventage in improving UCVA,correcting refractions, reducing the total HOA, and. spherica values.