AIM: To evaluate the safety and efficacy of laser in situ keratomileusis(LASIK)by Intralase femtosecond laser or Amadeus II microkeratome.

METHODS: Flap creation for LASIK was performed using IntraLase femtosecond laser(Intralase group)or Amadeus II microkeratome(Amadeus group)in 130 eyes with ametropia. Patients of Intralase group and Amadeus group were divided into three groups with different refractive degrees: ≤-3.00D was A, -3.00RESULTS: One month after LASIK, the postoperative vision of 60 eyes(93.7%)were the same as or better than preoperative BCVA in Intralase group and the postoperative vision of 61 eyes(92.4%)were the same as or better than preoperative BSCVA in Amadeus group. There was no significant difference between two groups(P=0.421). There was no significant difference in RMS values, spherical aberration, coma and trefoil between the groups in refractive degrees.

CONCLUSION: There is no significant difference in postoperative vision, RMS values, spherical aberration, coma and trefoil between Intralase femtosecond laser group and Amadeus Ⅱ microkeratome group. Both methods are effective and safe.