AIM: To evaluate the safety of the laser peripheral iridoplasty(LPIP)for the early-stage chronic primary angle-closure glaucoma(ECPACG).

METHODS: Sixty-five eyes of 36 patients with ECPACG received LPIP. At preoperative and postoperative, patients were examined with intraocular pressure(IOP), anterior chamber, optical coherence tomography(OCT), visual acuity, visual field, fundus and complications. The mean follow-up was 18.2±6.7mo(ranged 12～24mo).

RESULTS: The preoperative average IOP were 23.8±5.6mmHg, postoperative 1wk, 1, 3, 6, 12mo and in the last follow-up time the average IOP were 18.7±3.8, 17.9±3.2, 17.6±3.5, 18.4±3.7, 18.6±3.7, and 18.6±7.8mmHg. There was statistical difference comparing with preoperative(P<0.05, decreasing average 6.5±3.1mmHg compared with the preoperative, the difference was statistically significant(t=5.32, P<0.05). Postoperative 1wk, 1, 3, 6mo, the trabecular-iris angle(TIA500)and the angle opening distance at 500μm(AOD500)had the statistical difference comparing with preoperative(P<0.05). At Postoperative 1a and the last follow-up time, the TIA500 and AOD500 did not have statistical difference comparing with preoperative(P>0.05). The postoperative visual acuity, visual field, fundus had not changed. There were no complications found.

CONCLUSION:LPIP is safe, and has the short time effect in the treatment of ECPACG. With elapse of time, the effect of LPIP is weakened. We can repeat the treatment.