AIM:To investigate VEGF expression at various stages of diabetic rats eye disease through Meta analysis and then provide effective reference for clinical treatment.

METHODS:The randomized controlled experiment which studied the VEGF expression in the course of diabetic eye disease and used diabetic rat model was screened by searching database including pubmed, EMBASE, Medline, CNKI, Wanfang, VIP. Jadad scale(5 points as the full marks)was used to assess the quality of the included literatures. Data synthesis was carried out by the fixed effect model after heterogeneity test. Subgroups were divided according to different experiment stages.

RESULTS:Eight high quality literatures were included, two literatures were excluded after heterogeneity test. Data synthesis showed that VEGF expression in intraocular tissue of diabetic rats increased by 1.62%\〖95%CI(1.20～2.03),P<0.01\〗.

CONCLUSION:VEGF expression in intraocular tissue of diabetic rats is increased in each stage and gradually decreases monthly from two to six months.