AIM:To observe the long-term effect and influence factors of trabeculotomy in primary infantile glaucoma.

METHODS: The clinical data of 172 infants(257 eyes)with primary glaucoma was analyzed. After the follow-up visits, the change of postoperative intraocular pressure was observed. Upon the rising intraocular pressure, the operation was considered to be failure as long as 1 or 2 kinds of drugs were taken to ineffectively reduce the pressure. Based on the multivariate Logistic regression analysis, the risk factors for the failure of trabeculotomy were analyzed. Through Cox regression analysis, the influence factor of successful operation and the curve for success rate of operation at each time point was drawn.

RESULTS: The median time of follow-up visits was 30.7(8.4～57.9)mo and follow-up rate was 89.02%. Through the multivariate Logistic regression analysis, the preoperative intraocular pressure and corneal transparency were the high risk factors for the failure of trabeculotomy(P<0.05); through Cox regression analysis, the corneal transparency was the influence factor for the successful time of trabeculotomy(P<0.05).

CONCLUSION: Compared with preoperative intraocular pressure, the corneal transparency can reflect the severity of primary infantile glaucoma in a securer way. The scores of preoperative corneal transparency and detection of intraocular pressure can predict the control effect of postoperative intraocular pressure.