Age-related macular degeneration(AMD)is one of the leading causes of senile irreversible blindness. The oxidative stress caused by reactive oxygen species(ROS), as a risk factor of AMD, plays a role in the pathogenesis of AMD. Manganese superoxide dismutase(MnSOD), as one of the first line antioxidant enzymes, could be expressed in retina cells.It has been demonstrated that MnSOD is correlated with AMD and has been confirmed in animals, cellular level, and patients. This article reviewed the recent literatures on the research and progress of the relation between MnSOD and AMD.