小梁切除术合并丝裂霉素联合视网膜冷凝治疗新生血管性青光眼
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Trabeculectomy combined with mitomycin and retinal condensation for neovascular glaucoma
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    摘要:

    目的:探讨小梁切除术合并丝裂霉素联合视网膜冷凝治疗新生血管性青光眼的疗效及对患者眼部血流动力学的影响。

    方法:将45例45眼采用改良小梁切除术联合睫状体视网膜冷凝治疗的新生血管性青光眼患者纳入本研究,观察术后疗效、视力、眼压及并发症等情况,并采用彩色多普勒成像技术检测患者健侧眼与患侧眼术前及术后2wk的眼部血流动力学指标。

    结果:术后6mo手术成功率为84%,功能性滤泡形成率为82%,并发症发生率为27%; 术后1、3、6mo的眼压均较术前显著降低(P<0.05),且术后1、3、6mo的矫正视力较术前显著提高(P<0.05); 术后1、3、6mo患侧眼血流动力学参数PSV、EDV、RI均较术前显著改善(P<0.05)。

    结论:小梁切除术合并丝裂霉素联合视网膜冷凝治疗新生血管性青光眼的手术成功率高,能有效控制患者眼压,改善视力和眼部血流动力学指标。

    Abstract:

    AIM:To study the clinical effect of trabeculectomy combined with mitomycin and retinal condensation on neovascular glaucoma and their influence on ocular hemodynamics.

    METHODS:A total of 45 patients(45 eyes)with neovascular glaucoma treated with trabeculectomy, mitomycin and retinal condensation were selected, and the postoperative clinical effect, visual acuity, intraocular pressure(IOP)and complications were observed. The color Doppler imaging technique was used to detect hemodynamics index of contralateral and ipsilateral eye before and 2wk after surgeries.

    RESULTS:All the patients were followed up for 3~6mo. The successful rate was 84%, the rate of forming functional filtering bleb was 82%, and the complication rate was 27%. The IOP at 1, 3 and 6mo after surgeries decreased significantly compared with pre-operation(P<0.05), and the corrected visual acuity improved significantly at 1, 3 and 6mo after treatments(P<0.05); at 1, 3 and 6mo after treatments, the hemodynamic parameters including PSV, EDV, RI of ipsilateral eye improved significantly compared with those before surgeries(P<0.05).

    CONCLUSION:Trabeculectomy combined with mitomycin and retinal condensation has high success rate on treating neovascular glaucoma, which can effectively control IOP, improve vision and ocular hemodynamics.

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邱跃生,孙小林,吴琛.小梁切除术合并丝裂霉素联合视网膜冷凝治疗新生血管性青光眼.国际眼科杂志, 2016,16(4):630-632.

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  • 收稿日期:2015-12-28
  • 最后修改日期:2016-03-04
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  • 在线发布日期: 2016-03-28
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