AIM: To systematically evaluate the change of vision and diopter in 1wk to 1a in the patients with high myopia receiving orthokeratology treatment.

METHODS: Such databases as PubMed, EMbase, CBM, CNKI, VIP, and WanFang Data were searched. The retrieval time was from inception to September 2015, and the language was in both Chinese and English. After extracted the data and assessed the quality of the included studies, the Meta-analysis was performed by using RevMan 5.3 software.

RESULTS: A total of 6 studies involving 909 eyes were included. The results of Meta-analysis showed that, compared with that before wearing orthokeratology, the visual acuity improved in orthokeratology group at 1wk, 1, 3, 6mo and 1a \〖1wk: MD=-0.34, 95%CI(-0.55, -0.14), P=0.001; 1mo: MD=-0.50, 95%CI(-0.69, -0.30), P<0.01; 3mo: MD=-0.54, 95%CI(-0.70, -0.37), P<0.01; 6mo: MD=-0.49, 95%CI(-0.50, -0.47), P<0.01; 1a: MD=-0.46, 95%CI(-0.64, -0.29), P<0.01\〗. After wearing orthokeratology 1a, diopter also be effectively controlled \.

CONCLUSION: Orthokeratology is an effective control method to correct high myopia and high myopia development. But further studies are still required for its long-term effect.