AIM: To evaluate the changes of corneal endothelium density, central corneal thickness, corneal curvature and eye axial length for teenager myopia patients after wearing orthokeratology over night for 6mo.

METHODS: Retrospective case-observational study was adopted.Forty-four myopia teenagers(86 eyes)aged 7～17 wearing overnight orthokeratology contact lens were observed and analyzed using ultrasonic diagnostic apparatus, non-contact corneal endothelial microscope and corneal topography. Changes and relative coefficient of corneal endothelium density, central corneal thickness, corneal curvature and eye axial length were examined before and after wearing overnight orthokeratology contact lens for 6mo.

RESULTS:After wearing over night orthokeratology contact lens half a year, visual acuity was stable at 1.0～1.2 without serious complications. No significant differences were found in the density of corneal endothelial cells, corneal curvature and depth of anterior chamber comparing to before wearing. Central cornea thickness was smaller and length of eye axis increased after wearing for 6mo and significant differences were seen(P<0.05). The coefficient of variation was observed between density of corneal endothelial cells and length of eye axis(right eye:P=0.005,left eye:P=0.013), central cornea thickness and length of eye axis(right eye:P=0.019,left eye:P=0.006)after wearing orthokeratology contact lens for 6mo.

CONCLUSION:After wearing overnight orthokeratology for 6mo, eye axis length still increased, corneal endothelial cells density decreased and central cornea thickness thinned.