AIM: To evaluate the clinical effect of trabeculectomy combined with biological amniotic membrane implantation and mitomycin C for acute primary angle closure glaucoma.

METHODS: Twenty-five cases(25 eyes)with acute primary angle closure glaucoma underwent trabeculectomy combined with biological amniotic membrane implantation and mitomycin C. Clinical observations were carried out on the postoperative visual acuity, intraocular pressure, anterior chamber formation, filtering bleb and complications.

RESULTS:Except one patient whose postoperative visual acuity decreased, the visual acuity of others did not changed or improved, and the visual acuity at 1, 3, 7d, and 1mo were significantly different(P<0.05). At 3d to 1wk after operations, the visual acuity reached stable state. There were statistically significant differences on intraocular pressure before and after operations in all patients(P<0.01). The intraocular pressure remained stable during 1a after surgeries. The operation also maintained anterior chamber, formed functional filtering blebs and reduced the risk of complications.

CONCLUSION: Trabeculectomy combined with biological amniotic membrane implantation and mitomycin C is a safe and effective method for acute primary angle closure glaucoma.