AIM:To explore the clinical effect of needle revision combined with 5-fluorouracil(5-FU)for the disfunctional blebs after trabeculectomy.

METHODS:Needle revision combined with subconjunctival injection of 5-FU treatment was conducted on 30 eyes in 26 patients with disfunctional blebs at clinic visits at 1～4wk immediately after trabeculectomy. The morphology, intraocular pressure(IOP)and complications of the filtering blebs were observed, and all the patients were followed up for 3mo.

RESULTS:The morphology of filtering blebs was normal in 24 eyes after needle revision treatment. The pre-treatment IOP was 26.4±2.8mmHg, and the post-treatment IOP was 14.1±1.1mmHg, and the difference was statistically significant(P<0.05). The cure rate was 70%(21 eyes), effective rate was 17%(5 eyes), and the total was 87%. Common complications included subconjunctival hemorrhage, corneal epithelium dot stripped and hyphema.

CONCLUSION:The combination of needle revision and 5-FU has a good effect for failed filtering blebs after trabeculectomy. It is worthy promotion in clinical treatment.