AIM: To compare postoperative anti-inflammation effect and safety between bromfenac sodium eye drops and pranoprofen eye drops in patients after laser epithelial keratomileusis(LASEK).

METHODS: In the prospective, randomized and controlled study, 100 patients(200 eyes)undergoing LASEK were randomized into the bromfenac sodium group(100 eyes)and control group(100 eyes). Patients in bromfenac sodium group received bromfenac sodium hydrate ophthalmic solution eye drops twice a day in 3d before surgery and 2wk after surgery, while the patients from the control group were given proanoprofen eye drops 4 times a day in the same period. At 1, 3, 5d, 1 and 3mo after surgery, irritative symptoms grade, duration of irritation, time for corneal epithelial healing, cornel haze, uncorrected visual acuity and intraocular pressure(IOP)were observed and compared between the two groups. Quantitative data were analyzed using independent samples t-test and ranked data were statistically analyzed using the Mann-Whiteney rank sun test.

RESULTS: There was no significant difference between two groups in irritative symptoms grade(P=0.317), neither was existed between two groups in uncorrected visual acuity after surgery(P>0.05). There was no statistical significance in the time for corneal epithelial healing between two groups(P=0.551).

CONCLUSION: Bromfenac sodium eye drops(1g/L)can achieve the same therapeutic effect as pranoprofen eye drops after LASEK.