AIM:To observe the clinical efficacy of intravitreal Lucentis injection combined with panretinal photocoagulation(PPR)and compound trabeculectomy for neovascular glaucoma(NVG).

METHODS:A total of 14 cases(14 eyes)with NVG were collected from January to November 2015. All cases were treated with intravitreal lucentis injection, PPR and compound trabeculectomy by turns. Intraocular pressure(IOP), visual acuity and the complications at pre-or post-surgery were recorded, respectively.

RESULTS: Followed up for 3-6mo, the average IOP preoperatively was significantly decreased than that detected at post-operation(18.00±6.70 vs 41.65±4.07mmHg, t=11.288, P<0.05). IOP less than 21mmHg with or without the usage of anti-intraocular pressure drugs was defined as the sign of successful or effective surgery, respectively. At the ultimate follow-up, 11 cases were successful, 2 cases were effective, and the success rate was 79%, effective rate was 14%. Only 1 case was applied cyclocryotherapy due to the uncontrolled IOP. Moreover, the results of visual acuity detection demonstrated that 6 eyes got a better visual acuity, 7 eyes remained the same condition and 1 case got no light perception. Meanwhile, 13 cases showed none iris neovascularization during the follow-up; 1 case got a reappearance of iris neovascularization on the third month, which was then dissolved subjected to the intravitreal lucentis injection in combination with PPR. One case developed post-operative hyphema and absorbed after 1wk. No shallow anterior chamber and eyeball atrophy happened.

CONCLUSION:Intravitreal lucentis injection combined with PPR and compound trabeculectomy is an effective and safe therapeutic strategy for the treatment of NVG.