AIM: To analysis the feasibility of selectively targeting +0.1μm total spherical aberration by personalized aspheric intraocular lens implantation.

METHODS:Seventy-four cases(82 eyes)were randomly divided into experimental and control group, the corneal spherical aberration with 6mm pupil diameter was measured with Pentacam before surgery. Patients in experimental group received TecnisZCB00, Hoya60AD and ADAPT-AO, three different aspheric intraocular lenses, and the principle as the total spherical aberration close to +0.1μm. Patients in control group received ADAPT-AO aspheric intraocular lens. The uncorrected visual acuity, best corrected visual acuity, corneal spherical aberration and total spherical aberration were measured after 3mo.

RESULTS:There was no statistically significant difference in the uncorrected visual acuity, best corrected visual acuity between the two groups(t=0.817, 0.343, P>0.05). The comparison of corneal spherical aberration of the two groups showed no statistical significance before and after surgery(t=0.688, 0.592, P>0.05). The difference of total ocular aberrations were statistically significant between two groups(t=5.408,P<0.05). In the experimental group, there were no significant difference in total ocular aberrations among the different intraocular lens group between preoperative predictive value and postoperative value(t=1.943, 2.033, 0.032, P>0.05). The prediction error of total ocular aberrations were positively correlated with the preoperative corneal spherical aberration(r=0.834, P<0.05).

CONCLUSION:The personalized aspheric intraocular lens implantation based on preoperative corneal spherical aberration is feasible. This method can reduce postoperative total ocular aberrations and make the aberrations close to the predictive value.