AIM: To observe the change in full-field electroretinogram(ERG)in patients with nonproliferative diabetic retinopathy(NPDR)after panretinal photocoagulation(PRP)2d and 2mo, and evaluate the effects of Difrarel protecting dark adaptation function.

METHODS: Fifty-five cases with NPDR were randomly divided into the observation group and the control group.Both groups were treated with panretinal photocoagulation.Difrarel tablets was added in the observation group,and Vitamin B was added in the control group. We administered these drugs to the patients for 2mo continuously and the changes in ERG were observed after 2d and 2mo treatment. The amplitude of wave b(bA), and the peak time of wave b(bT)were observed and the data were treated statistically with SPSS 20.0 and test t in pairs.

RESULTS: The bT of the two groups before and at 2mo treatment had no difference inner group or inter-group(P>0.05). But there was obvious difference in bA of control group at 2mo after treatment compared with before treatment(P<0.05), significantly more increased amplitude of observation group than that of control group(P<0.05).

CONCLUSION: The function of each layer of PDR's retina has been damaged obviously and cannot get well after PRP. The patients with diabetic retinopathy combined with Difrarel tablets and PRP can better restore vision and improve the dark adaptation function.