AIM: To study the impact on compliance and pattern visual evoked potential of optical drugs suppress combine with auxiliary therapy for children with ametropic amblyopia.

METHODS: Totally 122 cases(189 eyes)children with ametropic amblyopia from October 2014 to October 2015 were divided into observation group, 61 cases(95 eyes)and control group, 61 cases(94 eyes). The control group given comprehensive therapeutic apparatus, CAM training comprehensive therapy, the observation group received above-mentioned combined with optical drugs suppress therapy. At 4mo after treatment, therapy compliance, pattern visual evoked potential, clinical efficacy were compared between two groups.

RESULTS: At 4mo after treatment, the efficient rate of observation group was 92.6% which was significantly higher than that of control group 81.9%(χ²=4.895, P<0.05). Therapy compliance rate was 96.7%, significantly higher than that of control group 83.6%(χ²=4.895, P<0.05). P100 amplitude of observation group(15.18±1.68μV)was significantly higher than that of the control group(12.34±1.34μV). P100 latency of observation group(93.75±10.01ms)was significantly lower than the control group(106.37±10.21ms)(t=10.322, 7.865; P<0.05, P<0.001).

CONCLUSION: Optical drugs suppress combine auxiliary therapy helps to improve visual acuity level in children with ametropic amblyopia, which may be related to enhance children's compliance, adjust pattern visual evoked potential.