Late intraocular lens dislocation is one of the most severe late complications after phacoemulsification. It often occurs 3mo after the surgery. Different from early intraocular lens dislocation, late intraocular lens dislocation is caused by zonular dehiscence and contraction of the capsular bag many years after phacoemulsification. In recent years, the incidence of late intraocular lens dislocation gradually increases, having a risk of 0.1% after 10a and 1.7% after 25a. In the long-term follow-up patients who underwent cataract surgery, 90% had zonular insufficiency and capsular contraction. Among the multiple factors which may contribute to zonular weakness and capsular contraction, pseudoexfoliation is the most common cause, accounting for 50% of all the cases. Other risk factors include aging, high myopia, uveitis, trauma, previous vitreoretinal surgery, retinitis pigmentosa, diabetes mellitus, atopic dermatitis, previous acute angle-closure glaucoma attack, and connective tissue disorders. The understanding of these predisposing factors will suggest necessary preventions for high-risk patients in the future.