AIM: To investigate the efficacy and visual sensitivity of occlusion therapy combined training for children with ametropic amblyopia.

METHODS: Totally 85 children(85 eyes)with anisometropic amblyopia treated in our hospital from January 2013 to January 2015 were selected. All patients were given occlusion therapy combined training. Statistical analysis of clinical efficacy and visual sensitivity changes were taken, and the changes of visual acuity, AULCSF, S_max, Fr_max were analyzed.

RESULTS: The visual acuity after therapy was significantly better than that before treatment(1.12±0.29 vs 0.45±0.25, P<0.01); AULCSF, S_max and Fr_max all increased, the difference between the two groups was statistically significant(P<0.05). The sensitivity of the same spatial frequency was significantly higher than that before treatment, the difference was statistically significant(P<0.05), and the contrast sensitivity decreased gradually with the increase of spatial frequency. There were statistical differences in the total effective rate of different refractive degrees after treatment(P=0.001). Mild group and moderate group had no significant difference on the total clinical efficiency difference(χ²=3.091, P=0.079); between mild group and severe group total effective rate was significantly different(χ²=11.471, P=0.001); the moderate and severe groups total clinical efficiency were no significantly different(χ²=3.359, P=0.067). In addition, the total efficiency rate of wearing glasses under the age of 6 was significantly higher than that after 6 years old(95% vs 77%), statistical difference between the two groups was significant(P<0.05).

CONCLUSION: Masking therapy combined with comprehensive training, in the treatment of children with ametropic amblyopia, and wearing a corrective spectacles, is desirable, especially for children under 7 years of age.