Orthokeratology can change the shape of the cornea and control the growth of the eye axis through the special design of its inverse geometry, which has achieved significant clinical effect on adolescent myopia correction. Thus, it has been highly praised by the experts at home and abroad and widely used. Recent studies show that orthokeratology can control the myopia anisometropia and improve the binocular vision in myopic. This article introduces the latest research progress on the effect and mechanism of orthokeratology control myopia, the treatment of anisometropia, the influence of ocular accommodation parameters and improvement of the binocular vision.