AIM: To explore the effect and mechanism of latanoprost on open-angle glaucoma.

METHODS: Totally 100 patients with open angle glaucoma who had been seeking treatment in our hospital between August 2015 and August 2017 were selected as the research subjects. These patients were divided into an observation group and a control group according to the random table method, with 50 cases in each group. The control group was treated with timolol maleate eye drops, 1 drop per time, 2 times a day, treated consecutively for 12wk. The observation group was given latanoprost eye drops for treatment, 1 drop per time, 1 time a day, for a continuous treatment of 12wk. The IOP, ocular hemodynamics, visual field defects and adverse reactions in the two groups were compared.

RESULTS: Before treatment, there was no statistically significant difference found on the intraocular pressure between the two groups(P>0.05); at 4, 8, 12wk after the treatment, the intraocular pressure at different time points in the observation group was shown to be lower than that in the control group, where the difference was statistically significant(P<0.05). There was no statistically significant difference shown in the artery hemodynamics indexes of CRA and PCA before and after treatment in the control group(P>0.05); the indicators of EDV and PSV of CRA, PCA indicators in the observation group significantly increased, while the RI index decreased significantly, with the difference being statistically significant(P<0.05). Before treatment, there was no statistically significant difference in all of the visual field defects between the two groups before treatment(P>0.05); after treatment, however, the scope of visual field defects was shrunk in both groups, with changes in the observation group more significant than the control group, and the difference was statistically significant(P<0.05)There was no statistically significant difference registered in the incidence of adverse reactions between the two groups(P>0.05).

CONCLUSION: For patients with open angle glaucoma, latanoprost eye drops is with significant curative effects and of relatively high value, which can significantly reduce the intraocular pressure, improve the ocular hemodynamics, and reduce the scope of eye damage with high safety.