AIM: To investigate the efficacy of the combined treatment of Conbercept and panretinal photocoagulation(PRP)for neovascular glaucoma(NVG)with central retinal vein occlusion(CRVO).

METHODS: The clinical data of 100 NVG patients with CRVO treated in our hospital from May 2014 to May 2017 were retrospectively analyzed. In those, 50 patients treated with glaucoma filtering surgery combined with PRP were selected as control group, and based on this, 50 patients treated with intravitreal injection of conbercept were included in the observation group. The best corrected visual acuity(BCVA)before treatment, and after 7d, 1, 3, and 6mo treatment were compared. The intraocular pressure IOP of each period with the non-contact tonometer were also compared, the effect of surgery was evaluated by slit-lamp examination of neovascularization combined with intraocular pressure, and then recurrence rate and complication was recorded during 6mo follow-up.

RESULTS: No statistically significant difference was found between preoperative and after surgery at each time point(P>0.05). The intraocular pressure of the two groups was significantly lower than that of before the surgery, the observation group was significantly lower than that of the control group 7d and 1mo after surgery, and the difference was statistically significant(P<0.05). There was no statistically significant difference on IOP the 3 and 6mo after surgery between two groups(P>0.05). The operation success rate was 100% in the observation group and was 92% in the control group, the difference was statistically significant(P<0.05). The complete success rate of the observation group was 84%, which was significantly higher than 66% of the control group, the difference was statistically significant(P<0.05). The hyphema and recurrence rate of the observation group were significantly lower than those of the control group, the difference was statistically significant(P<0.05). There was no significant difference in the incidence of shallow anterior chamber and low intraocular pressure(P>0.05).

CONCLUSION: Preoperative intravitreal injection of conbercept combined with panretinal photocoagulation for neovascular glaucoma after central retinal vein occlusion make the pressure recovery and neovascularization time shorter with better surgical results, and can control the anterior chamber hemorrhage and reduce the recurrence rate.