AIM: To explore the effects of overnight orthokeratology lens and conventional frame glasses on the myopic diopter, uncorrected visual acuity and ocular parameters of myopia adolescent.

METHODS: Totally 102 cases of(204 eyes)of adolescent myopia patients were randomly divided into observation group and control group with 51 cases(102 eyes)in each group during April 2014 to April 2017. Control group was only given conventional frame glasses, and observation group was given overnight orthokeratology lens. The myopic diopter and uncorrected visual acuity(UCVA)before wearing glasses and at 1wk, 1, 3, 6mo and 1a of wearing glasses, and the ocular parameters before wearing glasses and at 1a after wearing glasses were observed in the two groups, and the occurrence of complications was compared between the two groups.

RESULTS: After 1wk to 1a of wearing glasses, the myopic diopter in observation group was gradually decreased(P<0.05), and there was no significant difference in control group(P>0.05), but there was statistically significant difference between-groups at different time points(P<0.05). After 1wk to 1a of wearing glasses, the UCVA in observation group showed a increasing tendency(P<0.05), and the UCVA in observation group after 6mo to 1a of wearing glasses was significantly higher than that in control group(P<0.05). At 1a after wearing glasses, the axial length, corneal endothelial cell density, central anterior chamber depth, and intraocular pressure in observation group were not significantly different from those before wearing glasses(P>0.05), and the axial length in control group was significantly longer than that before wearing glasses and that in observation group(P<0.05). The total incidence rates of complications in observation group and control group were 10.8% and 6.9% respectively(P>0.05).

CONCLUSION: Overnight orthokeratology lens for adolescent myopia can effectively correct the myopic diopter, and improve the uncorrected visual acuity. It is less harmful to the eyes and less complications, and it is safe and reliable in clinical application.