AIM: To investigate the clinical effect of ranibizumab combined with vitrectomy in treatment of diabetic retinopathy(DR)with neovascular glaucoma(NVG).

METHODS: Selected 198 patients from 2016-01 to 2018-02 DR merger NVG eye treated in our hospital according to the different treatments were divided into observation group(103 cases)and control group(95 cases). Preoperative observation group used by licensed joint resistance for the treatment of vitreous cut, for the treatment of the control group only with vitreous cut, vitreous cut after 10-15d Ⅱ period implementation Ahmed aqueous humor drainage valve implantation. The changes of intraocular pressure, BCVA and VEGF in the two groups after treatment were observed.

RESULTS: The time of vitrectomy, the number of neovascularization and electrocoagulation in the observation group were all lower than those in the control group(P<0.001). Observation group in the vitreous cut postoperative 1wk and Ⅱ Ahmed, a aqueous humor drainage valve implantation after 1mo BCVA, intraocular pressure was significantly lower than control group(P<0.001). Observation group stage Ⅱ Ahmed aqueous humor drainage valve implantation before VEGF and postoperative 1mo macular center thickness of the concave is lower than the control group(P<0.001). The total complication rate in the observation group was lower than that in the control group(10.7% vs 28.4%, P<0.05).

CONCLUSION: Licensed joint resistance for the treatment of vitreous cut DR merger NVG curative effect is distinct, and made them Ⅱ period Ahmed aqueous humor drainage valve implants difficulty falling, recovery of patients' visual acuity, intraocular pressure level is good.