The elevation of intraocular pressure(IOP)caused by aqueous humor obstruction is the main cause of glaucoma, and lowering IOP is still the main method of glaucoma treatment. Aqueous humor drainage is mainly through the traditional trabecular route and non-traditional uveoscleral route. More and more attention has been paid to reducing IOP through a non-pressure-dependent uveoscleral route in treatment of glaucoma. This article reviews the advances in treatment of glaucoma by using drugs and surgery through the uveoscleral route to reduce IOP.