SMILE(small incision lenticule extraction)is widely used in myopia correction because of its safety and predictability. SMILE-derived lenticule is a kind of good biomaterial that can be used to repair corneal ulcer and perforation, treat hyperopia, presbyopia, keratoconus and other ophthalmic diseases. It has the potential of becoming the research hotspot in the future. Therefore, this review summarizes the clinical research progress of SMILE-derived lenticule in the field of ophthalmology.