Heme oxygenase-1(HO-1)is one of the most widely distributed antioxidant enzymes in the body, which can catalyze the metabolism of heme to biliverdin, iron ion and carbon monoxide, and finally exert anti-inflammatory and anti-inflammatory effects. Oxidation and the like. In diseases such as corneal disease, cataract, glaucoma, and diabetic retinopathy, HO-1 expression is up-regulated to protect tissues from oxidative damage, and its overexpression is closely related to the occurrence and development of ocular tumors. This article reviews the recent research progress between HO-1 and its metabolic end products and ophthalmic diseases.