AIM:To explore the etiology, related factors and prevention of infectious endophthalmitis after age-related cataract surgery.

METHODS: A retrospective analysis of 1 365 age-related cataract patients admitted to our hospital from 2016-01/2018-01, statistics of the incidence of infectious endophthalmitis, and analysis of the pathogenic characteristics of infectious endophthalmitis and related risk factors.

RESULTS: Infective endophthalmitis occurred in 28 patients, and 36 pathogens were detected, including 9 strains of staphylococcus epidermidis(25.00%), 9 strains of pseudomonas aeruginosa(25.00%), and 8 strains of bacillus(22.22%). Pseudomonas aeruginosa and Bacillus have strong resistance to cefazolin, cefotaxime and amoxicillin; high sensitivity to cefoperazone-sulbactam and meropenem; staphylococcus to epidermidis erythromycin and azithromycin have strong drug resistance, and have high sensitivity to vancomycin, nitrofurantoin and minocycline. Multivariate regression analysis of Logistic, age(≥70 years), diabetes, operative time(≥15min), intraoperative vitreous spillover were independent risk factors for infectious endophthalmitis after age-related cataract surgery(P<0.05).

CONCLUSION: Infectious endophthalmitis pathogens after age-related cataract surgery are more common with Staphylococcus epidermidis, Pseudomonas aeruginosa, and Bacillus. Age(≥70 years), diabetes, operative time(≥15min), intraoperative vitreous spillover were independent risk factors for infectious endophthalmitis after age-related cataract surgery.