AIM: To investigate and analyze the influencing factors of diabetic retinopathy(DR)and the therapeutic effect of conbercept.

METHODS:Totally 157 patients with diabetes who were treated in our hospital from January 2018 to July 2019 were selected as the research objects to carry out ophthalmic examination. According to the results of the examinations, the prevalence of DR was counted and the patients were divided into DR group and non-DR group. The basic data and clinical data of the two groups were compared and analyzed. The risk factors of DR in diabetic patients were explored by univariate analysis and multivariate Logistic regression analysis. The patients in DR group were treated with conbercept, and the therapeutic effect of conbercept on DR patients was observed and evaluated.

RESULTS:According to the diagnosis survey, there are 44 DR patients in 157 diabetic patients, 63 eyes in total, the prevalence rate is 28.0%. Univariate analysis showed that there was no significant difference in gender, body mass index(BMI), smoking history, drinking history, education level, history of coronary heart disease and blood lipid history between DR group and non-DR group(P>0.05), while there was a significant difference between the two groups in the duration of diabetes, age, history of ophthalmic diseases, the use of hypoglycemic drugs, and the history of hypertension(P<0.05). Logistic multivariate analysis showed that age, long course of diabetes, history of ophthalmic diseases, history of hypertension, irregular use of hypoglycemic drugs were independent risk factors for DR in diabetic patients. The parafoveal macular thickness(PMT), vascular endothelial growth factor(VEGF), insulin-like growth factor-1(IGF-1)and best corrected visual acuity(BCVA-LogMAR)of DR patients were lower than those before treatment(P<0.05).

CONCLUSION: The incidence of DR in diabetes mellitus patients in our hospital is relatively high in recent years, and its disease induction is mainly affected by diabetes course(≥10 years), age(≥60 years old), history of ophthalmic diseases, taking of hypoglycemic drugs, history of hypertension and other risk factors. The treatment of DR patients with conbercept can achieve good therapeutic effect and promote the rapid recovery of vision.