Scretogranin III(Scretogranin III, Scg3/SgIII)is a newly discovered angiogenic factor. Related studies in vivo and in vitro have confirmed that Scg3 plays an important role in the formation of fundus neovascularization. In recent years, some progress has been made in the treatment of fundus neovascularization with Scg3 antibody. It's mechanism of action is different from Vascular endothelial growth factor(VEGF). Scg3 is only expressed in pathological neovascularization, but in normal blood vessels, never be expressed, it is a newly discovered angiogenic factor with high selectivity. This paper summarizes the latest progress about its molecular structure of Scg3, signal transduction pathways and their applications in retinal neovascularization, the aim is to provide a new treatment idea for retinal neovascularization and choroidal neovascularization.