The formation of neovascularization is not only the common pathological change of many important eye diseases, but also the basis of tumor growth and metastasis. this article introduced the relationship, application and related research of anti-angiogenic drugs in the field of ophthalmology and oncology, it also introduced the new ways of administration, facing problems and challenges now, as well as the benefits and side effects of neovascularization drugs in ophthalmology application. Through the discussion of this article, we should strengthen the communication and cooperation between ophthalmologists and oncologists in basic and clinical aspects.