AIM:To evaluate the clinical effect of human fibrin glue in pterygium excision combined with fresh amniotic membrane transplantation and its clinical value.

METHODS: This study was a prospective analysis of 153 pterygium excision patients(153 cases, 153 eyes)from March 2018-October 2018. The patients were randomly and evenly divided into two groups: observation group(78 eyes)and control group(75 eyes). In fibrin glue group, patients(78 eyes)underwent pterygium excision, and the bare selera was covered with fresh amniotic membrane using fibrin glue for graft adherence, while in suture group, patients(75 eyes), the an amaiotic membrane grafts was attached to the selera using 10-0 nylon sutures after pterygium excision. Record the surgical time and the degree of pain after surgery were evaluated at 2h, 1, 3, 5 and 10d(before sutures out)after surgery.

RESULTS: Average surgical time(14.5±3.6)min in fibrin glue group was significantly less than suture group(18.3±4.2)min(P<0.05). The scores of 2h and 1, 3, 5 and 10d(before thread removal)pain levels were statistically significant(F=39.939, 419.026, 28.410, all P<0.01). After surgery, the degree of pain of treatment group was significantly decreased compared to control group, the difference was statistically significant(P<0.01). There were significant differences in pain scores at different time points in each group(P<0.01). There were no significant differences in the 2 groups comparing treatment outcomes of the recurrence rate at the end of 12-month follow-up(P>0.05).

CONCLUSION: It not only significantly reduces the surgical time, but also minimizes postoperative discomfort when we use fibrin glue in pterygium excisions. But it cannot decrease the recurrence rate.