Lacrimal sac lymphoma: a case series and literature review

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Supported by the National Natural Science Foundation of China (No.81970835); the Science and Technology Commission of Shanghai Municipality, China (No.20Y11911200).

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    AIM: To study the clinical and pathological characteristics of the lacrimal sac lymphoma, which is rare but it is the major type of non-epithelial malignant tumor in the lacrimal sac region. METHODS: Sixty-four cases of malignant lacrimal sac tumors in our hospital from 1986 to 2020 were retrospectively reviewed. Eight cases of lacrimal sac lymphoma were carefully reviewed. RESULTS: There were five mucosal-associated lymphoid tissue (MALT) lymphomas, one diffused large B-cell lymphoma, one NK/T cell lymphoma, and one mantle cell lymphoma. All eight patients represented symptoms of epiphora with swelling in the lacrimal sac for a certain period of time and showed no signs of systemic involvement at the first time of clinical visits. They had received either chemotherapy or radiotherapy after surgery. Long-term follow-up (from 11 to 220mo) showed that, except one patient with MALT lymphoma died for unknown reasons at 104mo after surgery, the other 7 patients were all alive with no signs of local recurrence, neither in other organs. CONCLUSION: Non-epithelial malignant tumors of the lacrimal sac are rare and lymphoma is the major subtype.

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Feng-Xi Meng, Han Yue, Yi-Qun Yuan, et al. Lacrimal sac lymphoma: a case series and literature review. Int J Ophthalmol 2022;15(10):1586-1590

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  • Received:September 25,2021
  • Revised:June 20,2022
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  • Online: September 21,2022
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