Effectiveness of peripheral defocus spectacle lenses in myopia control: a Meta-analysis and systematic review
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Qiu-Ping Liu. Vitreoretinal Department, Affiliated Eye Hospital of Nanchang University, Nanchang University, Nanchang 330006, Jiangxi Province, China. liuqiuping1983@gmail.com


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Supported by National Natural Science Foundation of China (No.81960177); Jiangxi Provincial Science and Technology Grant (No.20192BAB205049); A research grant from Jiangxi Provincial Health Commission (No.202210723); Postgraduate Innovation Special Fund Project of Jiangxi Province (No.YC2021-S077).

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    AIM: To evaluate the effectiveness of peripheral defocus spectacle lenses (PDLs) in myopia control. METHODS: Literature retrieval on PubMed, Cochrane Library, Embase, and Web of Science databases, and the search time limit was from the establishment of each database to December 29, 2021 were conducted. Change of spherical equivalent refraction (SER) and axial change (AL) were extracted from the literatures that met the inclusion criteria, and RevMan5.3 software was used for Meta-analysis. RESULTS: A total of 4 randomized controlled trials (RCTs) were included in this Meta-analysis, involving 770 myopic children. The results showed that PDLs could delay the progression of myopia in children with myopia compared with single vision spectacle lenses (SVLs; WMD=0.21 D, 95%CI: 0.01, 0.41, P=0.04). However, there was no significant difference in controlling the growth of axial length (AL) in myopic children (WMD=-0.10 mm, 95%CI: -0.21, 0.01, P=0.07). The results of the effectiveness of myopia control between the two spectacle lenses showed that PDLs were more effective in controlling the progression of myopia (OR=5.73, 95%CI: 2.58, 12.70, P<0.001) and delaying the growth of AL (OR=44.25, 95%CI: 8.84, 221.58, P<0.001) than SVLs, and the differences were statistically significant. CONCLUSION: PDLs can control the progression of myopia compared with SVLs, but cannot delay the growth of AL, and the effectiveness of PDLs in myopia control better than SVLs.

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Ji-Xian Ma, Si-Wen Tian, Qiu-Ping Liu. Effectiveness of peripheral defocus spectacle lenses in myopia control: a Meta-analysis and systematic review. Int J Ophthalmol, 2022,15(10):1699-1706

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  • Received:January 18,2022
  • Revised:April 21,2022
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  • Online: September 21,2022
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