AIM: To evaluate the extent of significant posterior capsular opacification (PCO) after implanting polyme-thylmethacrylate (PMMA) and soft acrylic intraocular lenses. METHODS: A total of one hundred patients (110 eyes) undergoingintraocular lens(IOL) implant surgerywererandomly divided into two groups based on the type of IOL implanted: Group I: AcrySof (SA60AT) and Group II: PMMA (LX10BD). The density of posterior capsular opacification (PCO) was assessed 3, 6, 12 and 18 months after surgery by taking best corrected visual acuity (BCVA) and the digital photographs. RESULTS: At the end of 3 months postoperatively, the PCO density in the Group I (PMMA) increased significantly (3.6%) while no increase was found in the Group II (Acrylic). By the end of 18 months follow-up, the incidence of significant PCO was found to be less in the acrylic group (14.5%) as compared to the PMMA group (34.5%).On the basis of density, the PCO was more extensive with the PMMA lens than the AcrySof lens, which led to more severe visual loss. CONCLUSION: The intraocular implantation of the AcrySof IOL helps to reduce the incidence of PCO to a greater degree as compared to the PMMA IOL.