Citation:Sun HQ,Zhou ZY.Effect of ginsenoside-Rg3 on the expression of VEGF and TNF-α in retina with diabetic rats.Int J Ophthalmol 2010;3(3):220-223,doi:10.3980/j.issn.2222-3959.2010.03.09
Effect of ginsenoside-Rg3 on the expression of VEGF and TNF-α in retina with diabetic rats
  
Email this Article  Add to Favorites  Print
DOI:10.3980/j.issn.2222-3959.2010.03.09
Key Words:ginsenoside-Rg3  diabetic retinopathy  vascular endothelial growth factor  tumor necrosis factor-α
Fund Project:
     
AuthorInstitution
Hong-Quan Sun Department of Ophthalmology, the Affiliated Hospital of Medical College of Qingdao University, Qingdao , Shandong Province, China
Zhan-Yu Zhou Department of Ophthalmology, the Affiliated Hospital of Medical College of Qingdao University, Qingdao , Shandong Province, China
Hits: 1776
Download times: 1470
Abstract:
      AIM: To investigate the effect of ginsenoside-Rg3 on the expression of vascular endothelial growth factor (VEGF) and tumor necrosis factor-α (TNF-α) in retina with diabetic rats and its roles in preventing neovascularization in diabetes.

    METHODS: Sixty male Wistar rats were divided into 3 groups randomly: negative control group, diabetic control group and ginsenoside-Rg3 treatment group (5mg/kg, 0.2mg/mL) followed by establishing diabetic model. The expression of VEGF and TNF-α were measured after 8 weeks.

    RESULTS: There were significant differences among negative control group, diabetic control group and ginsenoside-Rg3 treatment group in the expression of VEGF and TNF-α (F =129.363, 211.992; all the P <0.01). VEGF and TNF-α expression were significantly higher in diabetic control group and ginsenoside-Rg3 treatment group than that in negative control group (P <0.01), with a significant reduction in ginsenoside-Rg3 treatment group than that in diabetic control group (P <0.01).

    CONCLUSION: Ginsenoside-Rg3 can down-regulate the expression of VEGF and TNF-α in retina, which may interfere in the development of diabetic retinopathy.

    

PMC FullText Html:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3340625/
Supplementary Material
PDF Fulltext  Download reader  HTML Fulltext   View/Add Comment