Citation:Lian HD,Ren B,Gao XW.Effects of minocycline on expression of bcl-2, bax in early retinal neuropathy of diabetes in rats.Int J Ophthalmol 2011;4(2):162-164,doi:10.3980/j.issn.2222-3959.2011.02.10
Effects of minocycline on expression of bcl-2, bax in early retinal neuropathy of diabetes in rats
  
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DOI:10.3980/j.issn.2222-3959.2011.02.10
Key Words:mincycline; bcl-2; bax; retina; diabetes
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Hai-Dong Lian Department of Ophthalmology, the First Affiliated Hospital of Medical College of Shihezi University, Shihezi , Xinjiang Uygur Autonomous Region, China
Bing Ren Department of Ophthalmology, No. 474 Hospital of Chinese PLA, Urumqi , Xinjiang Uygur Autonomous Region, China
Xiao-Wei Gao Department of Ophthalmology, No. 474 Hospital of Chinese PLA, Urumqi , Xinjiang Uygur Autonomous Region, China
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Abstract:
      AIM: To study the effect of the minocycline (MNC) on expression of bcl-2, bax in retinal nerve cells of rat with diabetes.

    METHODS: Male SD rats were randomly divided into negative control group, model control group and MNC treated group. Diabetes model was established by intraperitoneal injection of 60 mg/kg streptozotocin (STZ). The protein expressions of bcl-2 and bax in retina were detected by immunohistochemistry method.

    RESULTS: Compared with the negative control group, bax immunoreactive neurons in retina were increased significantly (P <0.01) in model control group. However, bax immun- oreactive neurons in retina in MNC treated group were significantly decreased (P<0.01). Compared with the model control group, bcl-2 immunoreactive neurons in retina were increased significantly(P <0.01) in MNC treated group.

    CONCLUSION: MNC can obviously decreased expression of bax and increased expression of bcl-2 in retina with DR. It is one of path of inhibiting impairment on retinal nerve cells with DR.

    

PMC FullText Html:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3340700/
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