Citation:Hu BJ,Hu YN,Lin S,Ma WJ,Li XR.Application of Lutein and Zeaxanthin in nonproliferative diabetic retin.Int J Ophthalmol 2011;4(3):303-306,doi:10.3980/j.issn.2222-3959.2011.03.19
Application of Lutein and Zeaxanthin in nonproliferative diabetic retin
  
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DOI:10.3980/j.issn.2222-3959.2011.03.19
Key Words:Lutein  Zeaxanthin  liquid high-resolution chromatography  contrast sensitivity  optical coherence tom- ography  visual acuity  nonproliferative diabetic retinopathy
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Bo-Jie Hu Tianjin Medical University Eye Center, Tianjin , China
Ya-Nan Hu Tianjin Medical University Eye Center, Tianjin , China
Song Lin Tianjin Medical University Eye Center, Tianjin , China
Wen-Jiang Ma Tianjin Medical University Eye Center, Tianjin , China
Xiao-Rong Li Tianjin Medical University Eye Center, Tianjin , China
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Abstract:
      AIM: To compare serum Lutein and Zeaxanthin (L/Z) concentrations between patients with nonproliferative diabetic retinopathy (NDR) and normal subjects, and to explore the effect of L/Z supplementation on serum L/Z level and visual function in NDR patients

    METHODS: Subjects were divided into three groups: 30 NDR patients supplied with Lutein 6mg/d and Zeaxanthin 0.5mg/d for three months (DR Group), 30 NDR patients without L/Z supplementation (DR Control Group) and 30 normal subjects (Control Group). Serum L/Z concentrations were measured by liquid high-resolution chromatography (HPLC). Visual acuity was recorded at baseline, 1 month, 2 months and 3 months post initial supplementation. Serum L/Z concentration were measured at baseline, 1 month and 2 months post initial supplementation. Contrast sensitivity (CS) and fovea thickness were recorded at baseline and 3 months post initial supplementation.

    RESULTS: Mean serum lutein concentrations in DR group were 0.0686±0.0296μg/mL and zeaxanthin concentration was 0.0137±0.0059μg/mL. The L/Z level of DR group was significantly lower compared to the control group( lutein: 0.2302±0.1308μg/mL,zeaxanthin: 0.0456±0.0266μg/m,P = 0.000). The concentration of lutein and zeaxanthin in the DR control group at base line was 0.0714±0.0357μg/mL and 0.0119±0.0072μg/mL, respectively. There was no significant change of L/Z concentration in the DR control group during the study. Serum L/Z concentrations of DR group increased significantly after supplementation(F=109.124,P=0.000;F=219.207,P=0.000).Visual acuity improved significantly after medication. Compared with pre-medication, the average CS values of 1.5cpd, 3cpd and 6cpd after three months increased significantly (P=0.030,0.013,0.008) and the foveal thickness decreased. (P=0.05)

    CONCLUSION: Serum L/Z concentrations in DR patients are significantly lower than those in normal subjects, and L/Z intake can improve the visual acuity, CS and macular edema in DR patients, suggesting that L/Z supplementation might be targeted as potential potential therapeutic agents in treating NDR.

    

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