Citation:Li N,Deng XG,He MF.Comparison of the SchirmerⅠtest with and without topical anesthesia for diagnosing dry eye.Int J Ophthalmol 2012;5(4):478-481,doi:10.3980/j.issn.2222-3959.2012.04.14
Comparison of the SchirmerⅠtest with and without topical anesthesia for diagnosing dry eye
Received:April 06, 2012  Revised:April 06, 2012
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DOI:10.3980/j.issn.2222-3959.2012.04.14
Key Words:dry eye  SchirmerⅠtest  tears  topical anesthesia
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Na Li State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou , Guangdong Province, China
Xin-Guo Deng State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou , Guangdong Province, China
Mei-Feng He State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou , Guangdong Province, China
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Abstract:
      AIM: To determine the value of Schirmer Ⅰtest (SⅠt) without anesthesia and with topical anesthesia for diagnosing dry eye (DE).

    METHODS: Totally 220 eyes in 110 patients, male (44) and female (66), (39.56±12.67) years old diagnosed with DE were examined. SⅠt without anesthesia was performed firstly, and 15 minutes later, it was applied again in the same person after topical anesthesia with 0.5% proparacaine hydrochloride eye drops. The wetting strips counted <10mm per 5 minutes were defined positive, while ≤5mm per 5 minutes were defined strong positive.

    RESULTS: The wetting length in SⅠt after topical anesthesia was significantly lower than that in SⅠt without anesthesia (P<0.001). The positive rate and strong positive rate of SⅠt after topical anesthesia were significantly higher than that of SⅠt without anesthesia (P<0.001). The positive rate and strong positive rate of SⅠt without anesthesia and the strong positive rate of SⅠt after topical anesthesia in patients with aqueous-deficiency dry eye (ADDE) were significantly higher than those in total patients whereas those in patients with evaporative dry eye (EDE) were significantly lower than those in total patients (P<0.001).

    CONCLUSION: SⅠt after topical anesthesia with 0.5% proparacaine hydrochloride eye drops is more objective and reliable than that without anesthesia in reflecting the status of DE, and its diagnostic value in patients with ADDE was even higher, making itself a meaningful evidence for the diagnosis and treatment of DE.

PMC FullText Html:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3428545/
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