Citation:Li C,Zhao GQ,Che CY,Lin J,Li N,Jia WY,Zhang QQ,Jiang N,Hu LT.Effect of corneal graft diameter on therapeutic penetrating keratoplasty for fungal keratitis.Int J Ophthalmol 2012;5(6):698-703,doi:10.3980/j.issn.2222-3959.2012.06.09
Effect of corneal graft diameter on therapeutic penetrating keratoplasty for fungal keratitis
Received:June 25, 2012  Revised:November 11, 2012
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DOI:10.3980/j.issn.2222-3959.2012.06.09
Key Words:keratoplasty  penetrating  eye infection  fungal  corneal graft
Fund Project:National Natural Science Foundation of China (No.81170825)
                          
AuthorInstitution
Cui Li Department of Ophthalmology, the Affiliated Hospital of Medical College, Qingdao University, Qingdao , Shandong Province, China
Gui-Qiu Zhao Department of Ophthalmology, the Affiliated Hospital of Medical College, Qingdao University, Qingdao , Shandong Province, China
Cheng-Ye Che Department of Ophthalmology, the Affiliated Hospital of Medical College, Qingdao University, Qingdao , Shandong Province, China
Jing Lin Department of Ophthalmology, the Affiliated Hospital of Medical College, Qingdao University, Qingdao , Shandong Province, China
Na Li Department of Ophthalmology, the Affiliated Hospital of Medical College, Qingdao University, Qingdao , Shandong Province, China
Wen-Yan Jia Department of Ophthalmology, the Affiliated Hospital of Medical College, Qingdao University, Qingdao , Shandong Province, China
Qiu-Qiu Zhang Tengzhou Central People's Hospital, Zaozhuang , Shandong Province, China
Nan Jiang Department of Ophthalmology, the Affiliated Hospital of Medical College, Qingdao University, Qingdao , Shandong Province, China
Li-Ting Hu Department of Ophthalmology, the Affiliated Hospital of Medical College, Qingdao University, Qingdao , Shandong Province, China
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Abstract:
      AIM: To evaluate the effect of corneal graft diameter on therapeutic penetrating keratoplasty (PKP) for fungal keratitis.

    METHODS: A total of 116 patients (116 eyes) suffered from fungal keratitis underwent PKP at the Affiliated Hospital of Medical College Qingdao University from May 2006 to May 2010. They were divided into two groups according to the corneal graft diameter. 64 eyes’ corneal graft diameter was 8.00mm or larger and 52 eyes’ graft diameter was smaller than 8.00mm. The follow-up time was 2 years. The postoperative visual acuity and complications were documented and compared.

    RESULTS: Sixty-two (96.88%) eyes and fifty (96.15%) eyes preserved eyeballs respectively in two groups. There was no statistical difference in postoperative visual acuity (P=0.961), corneal graft clear rate (P=0.132) or the incidence of recurred fungal infection (P=0.770) between two groups. But there was a higher incidence of graft rejection (P=0.020) and secondary glaucoma (P=0.039) in group with corneal graft diameter 8.00mm or larger.

    CONCLUSION: PKP is an effective treatment approach for fungal keratitis. There is a higher incidence of complications in large-diameter PKP for fungal keratitis. Effective, preventive and therapeutic measures can improve the prognosis.

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