Citation:Zhou HY,Hao JL,Wang S,Zheng Y,Zhang WS.Nanoparticles in the ocular drug delivery.Int J Ophthalmol 2013;6(3):390-396,doi:10.3980/j.issn.2222-3959.2013.03.25
Nanoparticles in the ocular drug delivery
Received:March 15, 2013  Revised:May 29, 2013
Email this Article  Add to Favorites  Print
DOI:10.3980/j.issn.2222-3959.2013.03.25
Key Words:nanoparticles  eye  drug delivery
Fund Project:Norman Bethune Program of Jilin University, China (No.2012230); Research Fund of Jilin Provincial Science and Technology Department (international cooperation item, No. 20120726)
              
AuthorInstitution
Hong-Yan Zhou Department of Ophthalmology, China-Japan Union Hospital of Jilin University, Changchun , Jilin Province, China
Ji-Long Hao Department of Ophthalmology, China-Japan Union Hospital of Jilin University, Changchun , Jilin Province, China
Shuang Wang Department of Ophthalmology, China-Japan Union Hospital of Jilin University, Changchun , Jilin Province, China
Yu Zheng Department of Ophthalmology, China-Japan Union Hospital of Jilin University, Changchun , Jilin Province, China
Wen-Song Zhang Department of Ophthalmology, the Second Hospital of Jilin University, Changchun , Jilin Province, China
Hits: 2951
Download times: 1245
Abstract:
      Ocular drug transport barriers pose a challenge for drug delivery comprising the ocular surface epithelium, the tear film and internal barriers of the blood-aqueous and blood-retina barriers. Ocular drug delivery efficiency depends on the barriers and the clearance from the choroidal, conjunctival vessels and lymphatic. Traditional drug administration reduces the clinical efficacy especially for poor water soluble molecules and for the posterior segment of the eye. Nanoparticles (NPs) have been designed to overcome the barriers, increase the drug penetration at the target site and prolong the drug levels by few internals of drug administrations in lower doses without any toxicity compared to the conventional eye drops. With the aid of high specificity and multifunctionality, DNA NPs can be resulted in higher transfection efficiency for gene therapy. NPs could target at cornea, retina and choroid by surficial applications and intravitreal injection. This review is concerned with recent findings and applications of NPs drug delivery systems for the treatment of different eye diseases.
PMC FullText Html:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3693026/
Supplementary Material
PDF Fulltext  Download reader  HTML Fulltext   View/Add Comment