Citation:Aksoy A,Aslankurt M,Aslan L,Gül ?,Garipard?? M,?elik O,Okumu? S,?zdemir M,?zdemir G.Ocular findings in children with thalassemia major in Eastern Mediterranean.Int J Ophthalmol 2014;7(1):118-121,doi:10.3980/j.issn.2222-3959.2014.01.22
Ocular findings in children with thalassemia major in Eastern Mediterranean
Received:June 26, 2013  Revised:August 29, 2013
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DOI:10.3980/j.issn.2222-3959.2014.01.22
Key Words:thalassemia major  ocular findings  tear function test  central corneal thickness  axial length
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Conflicts of Interest: Aksoy A, None; Aslankurt M, None; Aslan L, None; Gül ?, None; Garipard?? M, None; ?elik O, None; Okumu? S, None; ?zdemir M, None; ?zdemir G, None.
                          
AuthorInstitution
Adnan Aksoy Department of Ophthalmology, KSU Faculty of Medicine, Kahramanmara? 46050, Turkey
Murat Aslankurt Department of Ophthalmology, KSU Faculty of Medicine, Kahramanmara? 46050, Turkey
Lokman Aslan Department of Ophthalmology, KSU Faculty of Medicine, Kahramanmara? 46050, Turkey
?zlem Gül Department of Pediatric Haematology, KSU Faculty of Medicine, Kahramanmara? 46050, Turkey
Mesut Garipard?? Department of Pediatric Haematology, KSU Faculty of Medicine, Kahramanmara? 46050, Turkey
O?uz ?elik Department of Ophthalmology, Faculty of Medicine, Gaziantep University, Gaziantep 27240, Turkey
Seydi Okumu? Department of Ophthalmology, Faculty of Medicine, Gaziantep University, Gaziantep 27240, Turkey
Murat ?zdemir Department of Ophthalmology, KSU Faculty of Medicine, Kahramanmara? 46050, Turkey
G?khan ?zdemir Department of Ophthalmology, KSU Faculty of Medicine, Kahramanmara? 46050, Turkey
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Abstract:
      AIM: To investigate ophthalmologic findings in children with thalassemia major (TM) and compare the findings with healthy controls.

    

    METHODS: In a cross-sectional study, 43 children with thalassemia major from pediatric hematology outpatient clinics from two university hospitals and age/sex matched 47 healthy children were included in the study. After a complete ophthalmic examination, tear function tests including the Schirmer test, fluorescein tear break-up time (BUT), ultrasound pachymetry, and axial length measurement were performed. Obtained data was recorded for statistical analysis and the values of right eyes were compared between groups.

    

    RESULTS: The mean best corrected visual acuity was 1.34±0.75 in TM and 1.08±0.28 in controls. It was found lower than 0.1 logMAR unit in 10 (23.2%) children with TM and 2 (4.2%) in controls, and the difference was statistically significant (P<0.05). The mean central corneal thickness was 540±26.95 in children with TM and 536.98±20.45μm in controls (P>0.05). The mean axial length was 22.53±0.50 in TM and 22.57±0.43mm in the control group. The mean Schirmer test score was 19.94±6.91 in TM and 24.22±3.95mm in the control group (P<0.01). The mean BUT score was 9.62±1.28 in TM and 9.73±0.6s in the control group (P>0.05).

    

    CONCLUSION: In TM, while corneal thickness, axial length, and BUT are close to controls, the Schirmer scores are less than normal. The study revealed that TM may be affected by the tear function and visual acuity.

    

    

PMC FullText Html:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3949471/
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