Citation:Patel V,Hawy EE,Waisbourd M,Zangalli C,M D. Shapiro,Lalita Gupta,Michael Hsieh,Abigail Kasprenski,L. Jay Katz,George L. Spaeth.Long-term outcomes in patients initially responsive to selective laser trabeculoplasty.Int J Ophthalmol 2015;8(5):960-964,doi:10.3980/j.issn.2222-3959.2015.05.19
Long-term outcomes in patients initially responsive to selective laser trabeculoplasty
Received:December 21, 2014  Revised:February 03, 2015
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DOI:10.3980/j.issn.2222-3959.2015.05.19
Key Words:selective laser trabeculoplasty  long-term  intraocular pressure  number of medications used  maximally tolerated medical therapy  glaucoma
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Varun Patel Glaucoma Research Center, Wills Eye Hospital, Philadelphia 19104, USA
Eman El Hawy Glaucoma Research Center, Wills Eye Hospital, Philadelphia 19104, USA
Michael Waisbourd Glaucoma Research Center, Wills Eye Hospital, Philadelphia 19104, USA
Camila Zangalli Glaucoma Research Center, Wills Eye Hospital, Philadelphia 19104, USA
Daniel M. Shapiro Glaucoma Research Center, Wills Eye Hospital, Philadelphia 19104, USA
Lalita Gupta Glaucoma Research Center, Wills Eye Hospital, Philadelphia 19104, USA
Michael Hsieh Glaucoma Research Center, Wills Eye Hospital, Philadelphia 19104, USA
Abigail Kasprenski Glaucoma Research Center, Wills Eye Hospital, Philadelphia 19104, USA
L. Jay Katz Glaucoma Research Center, Wills Eye Hospital, Philadelphia 19104, USA
George L. Spaeth Glaucoma Research Center, Wills Eye Hospital, Philadelphia 19104, USA
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Abstract:
      AIM:To determine the long-term effects of selective laser trabeculoplasty (SLT) on intraocular pressure (IOP) and the number of medications used up to 5y following treatment in glaucoma patients receiving maximally tolerated medical therapy (MTMT).

    METHODS:The Wills Eye Hospital Glaucoma Research Center retrospectively reviewed the charts of glaucoma patients who underwent SLT after receiving MTMT. Eyes that did not achieve their target pressure within 3mo following SLT were excluded from the study. Changes in mean IOP and number of glaucoma medications used were analyzed at 1, 3, and 5y following SLT.

    RESULTS:Seventy-five eyes of 67 patients were included in the study. Fifteen eyes that received SLT failed to achieve their target pressure within 3mo and were excluded from the study. The average follow-up time was 37.4mo (±14.4). Mean IOP was significantly reduced 1y after treatment (P=0.005). It was also reduced 3, 5y after treatment without reaching statistical significance (P=0.20 and P=0.072, respectively). There was a significant decrease in mean number of medications used 1, 3, 5y after treatment (P<0.001, P<0.001, and P=0.039, respectively). In the span of 5y, 2 eyes (2.7%) underwent repeat SLT, 7 eyes (9.3%) underwent glaucoma surgery and an additional 3 eyes (4.0%) underwent both.

    CONCLUSION:SLT significantly reduced the number of glaucoma medications used 5y following treatment in glaucoma patients receiving MTMT. SLT may delay operating-room surgery.

PMC FullText Html:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631010/
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