Citation:Yuksel-Elgin C,Elgin C.Intraocular pressure elevation after intravitreal triamcinolone acetonide injection: a Meta-analysis.Int J Ophthalmol 2016;9(1):139-144,doi:10.18240/ijo.2016.01.23
Intraocular pressure elevation after intravitreal triamcinolone acetonide injection: a Meta-analysis
Received:January 23, 2015  Revised:April 24, 2015
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Key Words:intravitreal injections  intraocular pressure  Meta-analysis
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Cansu Yuksel-Elgin Department of Ophthalmology, Sariyer Ismail Akgun Public Hospital, Sariyer-Istanbul 34450, Turkey
Ceyhun Elgin Department of Economics, Bogazici University, Istanbul 34342, Turkey
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      AIM: To report on intraocular pressure (IOP) after intravitreal injections of triamcinolone acetonide.

    METHODS: Systematic literature review of studies that investigated the effects of an injection of triamcinolone intravitreal triamcinolone acetonide on IOP was conducted according to the Cochrane Collaboration methodology and the reported effects have been analyzed with Meta-analysis.

    RESULTS: We found that the IOP follows an inverted-U shape pattern over time starting with an average value of 14.81±1.22 mm Hg before the injection, rising to a maximum of 19.48±2.15 mm Hg after one month of injection and falling down to 16.16±1.92 mm Hg after 6mo. Moreover, country of study, age, previous history of glaucoma and gender compositions matter for cross-study were different in reported IOP changes.

    CONCLUSION: Our findings may be helpful in determining pressure elevation risk of intravitreal triamcinolone acetonide therapy as well as comparing it with those of more recent therapies such as the anti-vascular endothelial growth factor agents.



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