Citation:Tong Y,Zhou YL,Zheng Y,Biswal M,Zhao PQ,Wang ZY.Analyzing cytokines as biomarkers to evaluate severity of glaucoma.Int J Ophthalmol 2017;10(6):925-930,doi:10.18240/ijo.2017.06.15
Analyzing cytokines as biomarkers to evaluate severity of glaucoma
Received:September 28, 2016  Revised:February 06, 2017
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DOI:10.18240/ijo.2017.06.15
Key Words:glaucoma  cytokines  intraocular pressure
Fund Project:Supported by the National Natural Science Fundation of China (No.81371040); Shanghai Pujiang Program (No.15PJD028); Scientific Research Project of Shanghai Municipal Health Bureau (No.20124149).
                 
AuthorInstitution
Yao Tong Department of Ophthalmology, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai , China; Department of Ophthalmology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai , China
Ya-Li Zhou Department of Ophthalmology, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai , China
Yan Zheng Department of Ophthalmology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai , China; Department of Ophthalmology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Chongming Branch, Shanghai , China
Manas Biswal Department of Molecular Genetics, University of Florida, Gainesville, Florida 32610, USA
Pei-Quan Zhao Department of Ophthalmology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai , China
Zhao-Yang Wang Department of Ophthalmology, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai , China
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Abstract:
      AIM: To analyze cytokines as biomarkers for evaluation of severity of glaucoma.

    METHODS: This was a prospective case-control study including 29 eyes with glaucoma. Besides, 28 eyes with senile cataract were used as control. Patients were classified into four groups: acute angle closure glaucoma (AACG), chronic angle closure glaucoma (CACG), primary open angle glaucoma (POAG) and senile cataract. Undiluted vitreous samples were collected, then vitreous concentrations of 9 types of cytokines were determined by cytometric bead assay system: γ-interferon (IFNg), interleukin (IL)-10, IL-2, IL-4, IL-5, interferon-γ-inducible protein (IP)-10, monocyte chemoattractant protein (MCP)-1, tumor necrosis factor (TNF) -α, and vascular endothelial growth factor (VEGF). We also recorded the intraocular pressure (IOP) of patients in each group and Pearson correlated analysis was performed to analysis the correlation between each type of cytokine with IOP.

    RESULTS: Vitreous levels of IL-2, IL-5, MCP-1, TNF-α and IP-10 were significantly higher (P<0.05) in AACG group. Patients with AACG, CACG and POAG have higher IOP than senile cataract, but we didn’t find any significant correlation between IOP with any type of the cytokines.

    CONCLUSION: Inflammation and immune reaction have a strong link with the pathology of glaucoma especially AACG. Some cytokines may act as biomarkers to evaluate the severity of glaucoma. Anti-inflammatory treatments and controlling of IOP are necessary for the therapy of glaucoma.

PMC FullText Html:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5515140/
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