Citation:Mastropasqua R,Toto L,Mastropasqua A,Aloia R,Nicola CD,Mattei PA,Marzio GD,Nicola MD,Antonio LD.Foveal avascular zone area and parafoveal vessel density measurements in different stages of diabetic retinopathy by optical coherence tomography angiography.Int J Ophthalmol 2017;10(10):1545-1551,doi:10.18240/ijo.2017.10.11
Foveal avascular zone area and parafoveal vessel density measurements in different stages of diabetic retinopathy by optical coherence tomography angiography
Received:March 28, 2017  Revised:August 28, 2017
Email this Article  Add to Favorites  Print
DOI:10.18240/ijo.2017.10.11
Key Words:optical coherence tomography angiography  diabetic retinopathy  fluorescein angiography
Fund Project:
                          
AuthorInstitution
Rodolfo Mastropasqua Ophthalmology Clinic, University of Marche, Ancona 60126, Italy
Lisa Toto Ophthalmology Clinic, Department of Medicine and Science of Ageing, University G. d'Annunzio Chieti-Pescara, Chieti 66100, Italy
Alessandra Mastropasqua Ophthalmology Clinic, Department of Medicine and Science of Ageing, University G. d'Annunzio Chieti-Pescara, Chieti 66100, Italy
Raffaella Aloia Ophthalmology Clinic, Department of Medicine and Science of Ageing, University G. d'Annunzio Chieti-Pescara, Chieti 66100, Italy
Chiara De Nicola Ophthalmology Clinic, Department of Medicine and Science of Ageing, University G. d'Annunzio Chieti-Pescara, Chieti 66100, Italy
Peter A Mattei Ophthalmology Clinic, Department of Medicine and Science of Ageing, University G. d'Annunzio Chieti-Pescara, Chieti 66100, Italy
Guido Di Marzio Ophthalmology Clinic, Department of Medicine and Science of Ageing, University G. d'Annunzio Chieti-Pescara, Chieti 66100, Italy
Marta Di Nicola Department of Experimental and Clinical Sciences, Laboratory of Biostatistics, University G. d'Annunzio Chieti-Pescara, Chieti 66100, Italy
Luca Di Antonio Ophthalmology Clinic, Department of Medicine and Science of Ageing, University G. d'Annunzio Chieti-Pescara, Chieti 66100, Italy
Hits: 101
Download times: 45
Abstract:
      AIM: To investigate foveal avascular zone (FAZ) and parafoveal vessel densities (PRVD) by means of optical coherence tomography angiography (OCTA) in diabetic patients with or without diabetic retinopathy (DR) and to assess the reproducibility of FAZ and PRVD measurements.

    METHODS: Sixty diabetic patients (60 eyes) with different stage of DR (graded according to the International Clinical Severity Scale for DR) and 20 healthy subjects underwent FAZ area and PRVD measurements using OCTA by two experienced examiners. FAZ area in all patients was also assessed using fluorescein angiography (FA).

    RESULTS: In subject with proliferative DR and with moderate-severe non proliferative DR, FAZ area was significantly increased compared to healthy controls (P=0.025 and P=0.050 respectively measured with OCTA and P=0.025 and P=0.048 respectively measured with FA). OCTA showed significantly less inter-observer variability compared to FA. Concordance correlation coefficient (CCC) for FAZ area measurements was 0.829 (95%CI: 0.736-0.891) P<0.001 with FA and 1.000 (95%CI: 0.999-1.000) P<0.001 with OCTA. CCC was 0.834 (95%CI: 0.746-0.893) P<0.001 and 0.890 (95%CI: 0.828-0.930) P<0.001 for parafoveal superficial and deep vessel density measurements, respectively.

    CONCLUSION: OCTA shows progressive increase of FAZ area and reduction of PRVD in both superficial and deep plexus at increasing DR severity. FAZ area and PRVD measurements using OCTA are highly reproducible.

PMC FullText Html:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638976/
PDF Fulltext  Download reader  HTML Fulltext   View/Add Comment