Citation:Jiang N,Ye LH,Ye L,Yu J,Yang QC,Yuan Q,Zhu PW,Shao Y.Effect of mistletoe combined with carboxymethyl cellulose on dry eye in postmenopausal women.Int J Ophthalmol 2017;10(11):1669-1677,doi:10.18240/ijo.2017.11.06
Effect of mistletoe combined with carboxymethyl cellulose on dry eye in postmenopausal women
Received:October 25, 2016  Revised:June 13, 2017
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DOI:10.18240/ijo.2017.11.06
Key Words:mistletoe  carboxymethyl cellulose eye drops  dry eye  postmenopausal women  treatment
Fund Project:Supported by the National Natural Science Foundation of China (No.81460092, No.81660158 and No.81400372); Natural Science Key Project of Jiangxi Province (No.20161ACB21017); Youth Science Foundation of Jiangxi Province (No.20151BAB215016); Technology and Science Foundation of Jiangxi Province (No.20151BBG70223)
                       
AuthorInstitution
Nan Jiang Department of Ophthalmology, the First Affiliated Hospital of Nanchang University, Nanchang , Jiangxi Province, China
Lin-Hong Ye Department of Ophthalmology, the First Affiliated Hospital of Nanchang University, Nanchang , Jiangxi Province, China
Lei Ye Department of Ophthalmology, the First Affiliated Hospital of Nanchang University, Nanchang , Jiangxi Province, China
Jing Yu Department of Ophthalmology, the First Affiliated Hospital of Nanchang University, Nanchang , Jiangxi Province, China; Department of Acupuncture and Moxibustion, Hangzhou TCM Hospital, Hangzhou , Zhejiang Province, China
Qi-Chen Yang Eye Institute of Xiamen University, Xiamen , Fujian Province, China
Qing Yuan Department of Ophthalmology, the First Affiliated Hospital of Nanchang University, Nanchang , Jiangxi Province, China
Pei-Wen Zhu Department of Ophthalmology, the First Affiliated Hospital of Nanchang University, Nanchang , Jiangxi Province, China
Yi Shao Department of Ophthalmology, the First Affiliated Hospital of Nanchang University, Nanchang , Jiangxi Province, China
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Abstract:
      AIM: To investigate the protective effect of mistletoe combined with carboxymethyl cellulose eye drops on dry eye in postmenopausal women.

    METHODS: Sixty postmenopause female patients diagnosed of dry eye were assigned randomly to mistletoe combined with carboxymethyl cellulose eye drops treatment group (n=30) and control group treated with normal saline eye drops (n=30). The subjective symptoms of ocular surface, Ocular Surface Disease Index (OSDI), tear film function tests, tear protein and corneal morphology by confocal scanning microscopy were analyzed before treatment and at 1, 2, 4 and 8wk after treatment respectively. To ensure the safety of the trial, all patients were examined with systolic pressure, diastolic pressure, glutamic-pyruvic transaminase, glutamic oxaloacetic transaminase, urine creatinine, and blood urea nitrogen at 8wk after treatment.

    RESULTS: There were no obvious differences between two groups before the treatment (P>0.05). In two months after the treatment, the symptoms of ocular surface, OSDI, tear protein, and tear film function were only slightly changed in normal saline eye drops group. However, all indices were improved after the treatment of mistletoe combined with carboxymethyl cellulose eye drops group (P<0.05). In addition, the average amount of corneal epithelium basal cells and inflammatory cells of mistletoe treated group were 3174±379 and 38±25 cells/mm2, significantly decreased as compared to the control group with 4309±612 and 158± 61 cells/mm2, respectively. In the control group, although nerves still maintained straight under corneal epithelium, the number of nerves were significantly decreased, as compared with normal female. In the mistletoe treated group, the number of nerves was only slightly reduced, compared with normal female.

    CONCLUSION: Mistletoe combined with carboxymethyl cellulose eye drops can alleviate the symptoms and signs of dry eye symptoms.

PMC FullText Html:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686364/
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