Citation:Hu YX,Xu XX,Shao Y,Yuan GL,Mei F,Zhou Q,Cheng Y,Wang J,Wu XR.The prognostic value of lymphocyte-to-monocyte ratio in retinopathy of prematurity.Int J Ophthalmol 2017;10(11):1716-1721,doi:10.18240/ijo.2017.11.13
The prognostic value of lymphocyte-to-monocyte ratio in retinopathy of prematurity
Received:November 18, 2016  Revised:June 01, 2017
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DOI:10.18240/ijo.2017.11.13
Key Words:neutrophil-to-lymphocyte ratio  monocyte-to-lymphocyte ratio  platelet-to-lymphocyte ratio  retinopathy of prematurity
Fund Project:Supported by National Natural Science Foundation of China (No.81360151; No.81760179); Natural Science Foundation of Jiangxi Province (No.20171BAB205046); Jiangxi Province Education Department Key Foundation (No.GJJ160033); Technology and Science Foundation of Jiangxi Province (No.20141BBG70027); Jiangxi Province Education Department Scientific Research Foundation (No.GJJ13147); Health Development Planning Commission Science Foundation of Jiangxi Province (No.20141031); Nanchang University Postgraduate Case Construction Project (No.0902-0210210802).
                          
AuthorInstitution
Yu-Xiang Hu Department of Ophthalmology, the First Affiliated Hospital of Nanchang University, Nanchang , Jiangxi Province, China
Xiao-Xuan Xu Department of Ophthalmology, the First Affiliated Hospital of Nanchang University, Nanchang , Jiangxi Province, China
Yi Shao Department of Ophthalmology, the First Affiliated Hospital of Nanchang University, Nanchang , Jiangxi Province, China
Gao-Le Yuan Department of Pediatrics, the First Affiliated Hospital of Nanchang University, Nanchang , Jiangxi Province, China
Feng Mei Department of Ophthalmology, the First Affiliated Hospital of Nanchang University, Nanchang , Jiangxi Province, China
Quan Zhou Department of Ophthalmology, the First Affiliated Hospital of Nanchang University, Nanchang , Jiangxi Province, China
Yi Cheng Department of Ophthalmology, the First Affiliated Hospital of Nanchang University, Nanchang , Jiangxi Province, China
Jun Wang Second Department of Respiratory Disease, Jiangxi Provincial People’s Hospital, Nanchang , Jiangxi Province, China
Xiao-Rong Wu Department of Ophthalmology, the First Affiliated Hospital of Nanchang University, Nanchang , Jiangxi Province, China
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Abstract:
      AIM: To evaluate the associations between development of retinopathy of prematurity (ROP) and serum lymphocyte-to-monocyte ratio (LMR), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR).

    METHODS: A retrospective cohort study was performed, involving infants who were screened for ROP from January 2015 to December 2015. Preterm newborns of ≤32 gestational weeks with ROP were enrolled as the observation group, and non-ROP infants were enrolled as the control group, whose complete blood cell were measured within the first 24h of life. The levels of NLR, LMR and PLR were determined in all groups. The data obtained were analyzed using univariate and multivariate logistic regression analysis.

    RESULTS: In this study, 40 cases of ROP were enrolled and 40 cases of non-ROP as controls. The LMR levels were significantly higher (P<0.001) in ROP group (3.96±1.16) compared to non-ROP group (2.85±0.79). The NLR levels were significantly lower (P=0.035) in ROP group {median [interquartile range (IQR)], 0.88 (0.67-1.46)} compared to non-ROP group [median (IQR), 1.20 (0.85-1.89)]. The median PLR values were 61.99 (IQR, 50.23-75.98) in ROP group and 69.24 (IQR, 55.52-88.12) in non-ROP group (P=0.104). Logistic regression analysis suggested that LMR was an independent risk factor for ROP (OR: 0.275; 95% CI: 0.134-0.564; P=0.001).

    CONCLUSION: The findings demonstrate that higher LMR is independently and significantly associated with the development of ROP, and the LMR may be invoked as a predictive tool for identifying risk for ROP.

PMC FullText Html:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686371/
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