IgG4 and IgE co-positive group found in idiopathic orbital inflammatory disease
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Jian-Min Ma. Beijing Ophthalmology & Vision Science Key Lab, Beijing Tongren Eye center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China. jmma@sina.com; Xue-Mei Ma. College of Life Science and Bio-engineering, Beijing University of Technology, Beijing 100124, China. xmma@bjut.edu.cn

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Supported by the National Natural Science of China (No.81602408; No.81371052).

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    Abstract:

    AIM: To reveal the cytokines involved in idiopathic orbital inflammatory disease (IOID) and the relationship between Th17 cells, IgE and IOID pathogenesis. METHODS: Whole blood samples were processed immediately after collection and serological IgG4, IgG, and IgE antibodies were tested using ELISA. IOID and orbital cavernous hemangioma (CH) tissue samples underwent Bio-Plex multiplex cytokine detection. Hematoxylin-Eosin (HE) staining of all paraffin samples suggested the histological features of IOIDs, and expressions of IgG4 and IL-17A in affected tissues were detected by immunohistochemistry. RESULTS: Among 40 IOID plasma samples, 52.5% (21/40) were positive for IgG4 and 25% (10/40) were positive for IgE. Overlapped IgG4 or IgE positive samples accounted for 22.5% (9/40). Therefore, IOID samples were separated into three groups. The IgE+/IgG4+ group had a relevantly lower level of pro-inflammatory cytokine expression. IL-4 (Th2 cell related), IL-10 and TGF-β1 (Treg cell immunity related) were elevated in all three groups. Some of the Th17 cell related cytokines (i.e. IL-17A/F, IL-25, IL-23, and IL-33) displayed higher expression levels in the IgE-/IgG4- group compared to the other two groups. CONCLUSION: We discovered an IgG4-IgE co-positive group as well as Th17 cell immune involvement in IgG4-IgE co-negative subgtroup in IOID for the first time. The pathogenesis of IOID could differ from different subgroups according to the IgG4 and IgE detection. Therefore, we recommend that, Treatment stratagy should be made according to the clinical assessment of IgG4-IgE and Th17 profile detection.

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Peng-Xiang Zhao, Yao Mawulikplimi Adzavon, Jian-Min Ma, et al. IgG4 and IgE co-positive group found in idiopathic orbital inflammatory disease. Int J Ophthalmol, 2018,11(1):36-42

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History
  • Received:January 03,2017
  • Revised:August 28,2017
  • Adopted:
  • Online: January 09,2018
  • Published: