Citation:Zhou YS,Xu J,Peng J,Liu Y,Qin GY,Yang YJ,Peng QH,Tan HY.Effect of Qingguang’an II on expressions of OX42 protein and IL-1β mRNA of retinal microglia cells of rats with chronic high intraocular pressure.Int J Ophthalmol 2018;11(2):326-328,doi:10.18240/ijo.2018.02.23
Effect of Qingguang’an II on expressions of OX42 protein and IL-1β mRNA of retinal microglia cells of rats with chronic high intraocular pressure
Received:May 05, 2017  Revised:December 22, 2017
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DOI:10.18240/ijo.2018.02.23
Key Words:Qingguang’an II; chronic high intraocular pressure; OX42 protein; interleukin-1β mRNA
Fund Project:Supported by the National Natural Science Foundation of China (No.81273807); Key Projects of Graduate Innovation Fund of Hunan Province (No.CX2017B434; No.CX2017B426); Projects of Hunan Educational Research Foundation (No.17C1221); 225 Engineering Project of High Lever Health Professionals of Hunan Province; Key Discipline Project of Ophthalmology of Traditional Chinese Medicine of State Administration of TCM; Key Discipline Project of Otorhinolaryngology of TCM of Hunan Province; Hunan Provincial Key Laboratory for the Prevention and Treatment of Ophthalmology and Otolaryngology Diseases with Traditional Chinese Medicine (No.2017TP1018).
                       
AuthorInstitution
Ya-Sha Zhou Hunan University of Traditional Chinese Medicine, Changsha , Hunan Province, China
Jian Xu Hunan University of Traditional Chinese Medicine, Changsha , Hunan Province, China
Jun Peng The First Affiliated Hospital of Hunan University of Traditional Chinese Medicine, Changsha , Hunan Province, China
Yue Liu Hunan University of Traditional Chinese Medicine, Changsha , Hunan Province, China
Gen-Yan Qin Hunan University of Traditional Chinese Medicine, Changsha , Hunan Province, China
Yi-Jing Yang Hunan University of Traditional Chinese Medicine, Changsha , Hunan Province, China
Qing-Hua Peng Hunan University of Traditional Chinese Medicine, Changsha , Hunan Province, China; The First Affiliated Hospital of Hunan University of Traditional Chinese Medicine, Changsha , Hunan Province, China
Han-Yu Tan Hunan University of Traditional Chinese Medicine, Changsha , Hunan Province, China
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Abstract:
      The study investigated the effects of Qingguang’an II (a Chinese medicinal preparation) on expressions of OX42 protein and interleukin-1β (IL-1β) mRNA of retinal microglia cells of rats with chronic high intraocular pressure (IOP). SD rats were randomly divided into 6 groups, that were: A: blank group; B: model group; C: Qingguang’an II low dose group; D: Qingguang’an II medium dose group; E: Qingguang’an II high dose group; F: Yimaikang disket (a Chinese medicinal preparation) group. Experimental rats in B, C, D, E, F groups were established the model of chronic high IOP by cauterizing of superficial scleral vein. Tissues of eyes were obtained after intragastric administration for 2 and 4wk. At the time-point of 2wk, OX42 protein and IL-1β mRNA in group B were statistically expressed in higher level comparing with other groups (P<0.05). Moreover, at the time-point of 4wk, OX42 protein and IL-1β mRNA in groups C, D and E were statistically expressed in lower level comparing with group F (P<0.05). Besides, OX42 protein and IL-1β mRNA in groups C and D were statistically expressed in higher level comparing with group E (P<0.05). OX42 protein and IL-1β mRNA in groups C and D were expressed in similar level (P>0.05). The study indicated that, in the protection of optic nerve of rats with chronic high IOP, the high dose of Qingguang’an II at the time-point of 4wk was the better choice.
PMC FullText Html:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824091/
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